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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2AK4
All Species:
12.42
Human Site:
S1057
Identified Species:
27.33
UniProt:
Q9P2K8
Number Species:
10
Phosphosite Substitution
Charge Score:
0.3
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9P2K8
NP_001013725.2
1649
186838
S1057
D
I
L
K
G
N
F
S
I
R
T
A
K
M
Q
Chimpanzee
Pan troglodytes
XP_001140245
1649
186793
S1057
D
I
L
K
G
S
F
S
I
R
T
A
K
M
Q
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_535431
1633
184740
I1060
N
M
P
K
G
F
S
I
R
T
S
K
I
Q
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q9QZ05
1648
186468
L1056
D
I
L
K
G
N
F
L
I
R
T
A
K
I
Q
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518247
1608
180821
S1016
D
V
L
K
G
S
F
S
I
R
A
A
K
I
Q
Chicken
Gallus gallus
XP_421203
1656
188583
S1063
D
T
L
K
G
S
F
S
V
W
G
A
K
I
Q
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_002667149
1483
168725
E945
M
E
E
S
E
L
H
E
V
L
Q
H
T
M
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_001120977
1130
130476
N592
S
V
K
L
M
T
R
N
G
N
I
V
C
I
P
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_785160
1605
181469
D1064
M
E
D
A
R
L
Q
D
M
L
H
Q
T
V
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LX30
1241
140303
E703
K
W
V
N
E
F
P
E
Q
A
S
L
L
R
R
Baker's Yeast
Sacchar. cerevisiae
P15442
1659
190175
N1037
P
T
S
T
P
F
A
N
I
L
R
S
Q
M
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
N.A.
89.7
N.A.
90.5
N.A.
N.A.
74.7
72.3
N.A.
52.6
N.A.
N.A.
27.9
N.A.
40.4
Protein Similarity:
100
99.9
N.A.
94.3
N.A.
94.9
N.A.
N.A.
84.4
84.5
N.A.
67.4
N.A.
N.A.
44
N.A.
59.4
P-Site Identity:
100
93.3
N.A.
20
N.A.
86.6
N.A.
N.A.
73.3
60
N.A.
6.6
N.A.
N.A.
0
N.A.
0
P-Site Similarity:
100
100
N.A.
40
N.A.
93.3
N.A.
N.A.
93.3
80
N.A.
13.3
N.A.
N.A.
20
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
22.5
26.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
39.7
46.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
10
0
0
10
0
0
10
10
46
0
0
19
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% C
% Asp:
46
0
10
0
0
0
0
10
0
0
0
0
0
0
0
% D
% Glu:
0
19
10
0
19
0
0
19
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
28
46
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
55
0
0
0
10
0
10
0
0
0
0
% G
% His:
0
0
0
0
0
0
10
0
0
0
10
10
0
0
0
% H
% Ile:
0
28
0
0
0
0
0
10
46
0
10
0
10
37
0
% I
% Lys:
10
0
10
55
0
0
0
0
0
0
0
10
46
0
0
% K
% Leu:
0
0
46
10
0
19
0
10
0
28
0
10
10
0
0
% L
% Met:
19
10
0
0
10
0
0
0
10
0
0
0
0
37
0
% M
% Asn:
10
0
0
10
0
19
0
19
0
10
0
0
0
0
0
% N
% Pro:
10
0
10
0
10
0
10
0
0
0
0
0
0
0
10
% P
% Gln:
0
0
0
0
0
0
10
0
10
0
10
10
10
10
55
% Q
% Arg:
0
0
0
0
10
0
10
0
10
37
10
0
0
10
10
% R
% Ser:
10
0
10
10
0
28
10
37
0
0
19
10
0
0
0
% S
% Thr:
0
19
0
10
0
10
0
0
0
10
28
0
19
0
10
% T
% Val:
0
19
10
0
0
0
0
0
19
0
0
10
0
10
0
% V
% Trp:
0
10
0
0
0
0
0
0
0
10
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _